I am working with GSEA results using GSEA pre ranked. My input is list of genes with their log2foldchange as the metric . The genes with log2foldchange were calculated using Differential expression.
Now in my GSEA results. I see this pathway plot. The pathway name is RB_P130_DN.V1_DN and its description in Msigdb database is "Genes down-regulated in primary keratinocytes from RB1 and RBL2".
So this pathway is upregulated in my experiment or downregulated ? Can someone explain this result ? I see that the genes in my experiment have a positive Enrichment score and the pathway seems to be upregulated to me. But then it does not correlate with the pathway as in that the genes go down ? https://ibb.co/mVWS5R