I have a honey bee Gene Regulatory network found here and Flynet contains the whole fly network. There are also tissue specific networks present in the list for flies. I am thinking of taking the head tissue network for fly and comparing it with the brain tissue network available from bees. I can convert most of the honey bee probe ids present in the list to refseq ids and the flybase ids present for the fly network can also hopefully be converted to the corresponding Refseq ids. However, I am unsure as to how an comparison can be done to find similar nodes. I am new to network comparison and would appreciate it if suggestions can be provided on how to compare these two diverse networks.