Question: how trustable are KEGG pathways?
gravatar for igor
22 months ago by
United States
igor8.8k wrote:

How trustable are KEGG pathways? I could not find any policy on their website.

I was looking at the KEGG publication, which is fairly bare-bones. The most helpful section seems to be:

The PATHWAY database is a collection of manually drawn diagrams called the KEGG reference pathway diagrams (maps), each corresponding to a known network of functional significance.

How do they define "known" or "significant" then?

kegg pathways • 670 views
ADD COMMENTlink modified 22 months ago by Mo890 • written 22 months ago by igor8.8k
gravatar for Mo
22 months ago by
Mo890 wrote:

It is one of the best databases for pathway discovery. However, you should never trust it fully. As far as I know, IPA is very trustable (but very expensive) because of the fact that they curate data manually. Most of the databases are based on text mining and ofcourse the FDR is rather high. All said, I would trust KEGG but approve it with orthogonal techniques

ADD COMMENTlink written 22 months ago by Mo890
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