how would I find SNPs that are highly polymorphic between populations in dbSNP

Question

[b10hazard]

Hi there,

I’m trying to get a vcd file containing SNPs that are highly polymorphic by population. Does anything like this exist in dbSNP? I’m guessing I would want to find SNPs with high fixation indexes between populations but I have no idea how to do this. Any advice would be great. Thanks!

Answer 1

[agata88]

This may help: How To Perform A Fst (Fixation Index) Calculation Over A Vcf File Using A Sliding Window?

You can download dbSNP database in vcf file and try vcftools to select those SNP of your interest.

Best, Agata