Core transcriptional regulatory network in human

Question

[Bioinformatist Newbie]

Hi,

I am looking for the known human core transcriptional regulatory networks whose interactions have been experimentally verified. For example, see the Figure 1 of this paper. There, they describe the core network for mouse ESC and muscle regulatory network. Similar to these, I am looking for such networks for other systems e.g. neural stem cells, osteoblast. I have used google but nothing significant has crossed my eyes, except some core networks for hematopoietic stem cells. If you know any such core network please share the reference to literature.

Thanks!

Answer 1

[Alex Reynolds]

If you're interested in specific genes and cell types, you might take a look at: http://www.regulatorynetworks.org/ which is the network browser for the linked paper (disclaimer: to which I contributed). Once you pick your combination of settings, you can export a table of regulator -> regulated relationships. If your cell types and genes are not listed, you might contact the lead authors for input.