convert amino acids between species
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3.5 years ago
igor 12k

The mouse homolog of TP53 is Tp53, but the specific sequence is obviously slightly different and the mouse equivalent of human R249S is R246S. For a few mutations, it's relatively simple to align the two gene sequences and visually inspect how they line up, but this is not really feasible if you have hundreds of them. Given a list of non-human mutations, is there an automated way to convert them to human equivalents?

There are a few different databases for determining gene homologs, but is there a resource for cross-species amino acid conversions? I expected to find a database somewhere, but I couldn't find one.

gene amino acid homology variants • 740 views
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Have you checked NCBI's homologene database. It provides MSA's which you could potentially query for the changes you are looking for.

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Thanks! I actually was not aware. But is there a better way than parsing pages like this? https://www.ncbi.nlm.nih.gov/homologene?cmd=Retrieve&dopt=MultipleAlignment&list_uids=460

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