Hi every one
Could anyone explain why a stop-loss is pathogenic? Like why causing an elongated protein is pathogenic?
because some extra amino acids could break the conformation of the protein -> active domain is broken.
closing as it's not related to bioinformatics.
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I'm closing this question as it's not related to bioinformatics.
For this reason we have closed your question. This allows us to keep the site focused
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Why a stoploss mutation is not related to bioinformatics? Shouldnot we understand the type of mutations we try to discover from data?
Because it's a basic concept of molecular biology, you would expect to find in good text books on the topic. As a rule of thumb, we do not attempt to explain basic concepts of molecular biology on this site that have better explanation elsewhere.