Postdoctoral positions are open in the newly established Functional Gene Control group at MRC London Institute for Medical Sciences (LMS) led by Dr Mikhail Spivakov (https://lms.mrc.ac.uk/research-group/functional-gene-control/). We combine experimental and computational approaches to study how genomic and epigenetic information is integrated with extrinsic signals to promote concerted changes in phenotype, such as in cell differentiation and activation. Our current focus is on the function of distal DNA elements such as enhancers in these processes, and on human primary cells as experimental systems. The projects will capitalise on the methodological foundations of our previous work on promoter-enhancer relationships, organisation of DNA regulatory elements and non-coding genetic variation.
The candidates will have a PhD, a strong background in a biomedical science or quantitative discipline (mathematics, statistics, physics, computer science), and advanced expertise in generating and interrogating data from high-throughput genomics assays using statistical and machine learning methodologies. Experience in the analysis of chromosomal interactions and cis-regulatory networks is particularly relevant, and a track record of devising novel experimental and/or computational techniques is desirable.
The ideal applicants will have a dual wet- and dry-lab expertise. However, exceptional candidates from either one of these backgrounds are also encouraged to apply.
The group is moving to the LMS from the Babraham Institute in Cambridge. For more information about our research and publications at Babraham, please see http://regulatorygenomicsgroup.org.
The post holders will join an international, multidisciplinary team within a collaborative and stimulating research environment, with strong links with other groups at the LMS and beyond.
Informal inquiries can be addressed to Dr Mikhail Spivakov (mikhail.spivakov at babraham.ac.uk).