How to perform eQTL study if i have small sample size?
1
0
Entering edit mode
2.8 years ago

Hi All,

I would like to study the variant effect in gene expression (eQTL) Currently, I am having 4 RNA seq sample for the disease condition. I would like to do eQTL study based on this sample. Is it feasible to do? relse can i download the microarray data from GEO and proceed further?. I am a beginner for an eQTL study. Please advice me.

eQTL GWAS SNP RNA-Seq • 1.2k views
ADD COMMENT
0
Entering edit mode
2.8 years ago

I would say this is impossible, usually QTL studies use hundreds of sequenced individuals. That permit a good heterogeneity of their genome due to random recombination and a good difference of segregation between molecular markers and phenotype.

ADD COMMENT
0
Entering edit mode

Hi, maxime! what's about 15 samples? is it appropriate to do QTL analysis? Or, is there any way to filter the MatrixEQTL results?

ADD REPLY

Login before adding your answer.

Traffic: 2346 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6