Tool: FusionHub: A unified web platform for annotation and visualization of gene fusion events in human cancer
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11 months ago by
pbpanigrahi180
pbpanigrahi180 wrote:

Hi all

I have recently developed a web platform, FusionHub, a single platform for gene fusion data analysis. It supports annotation, visualization and siRNA designing for fusion genes.

It has 4 modules

FusionSearch module

  • Allows to annotate fusion genes across 28 different fusion resources like
    • Cosmic, ChimerKB, ChimerPUB, ChimerSEQ, ChiTaRS, Farecafe, TicDB,Tumor Fusion Portal, FusionCancer, ConjoinG, 18Cancers, Oesophagus_Dataset, Gliomas_Dataset, Prostate_Dataset, Pancreases_Dataset, Klijin_Dataset, Known_Fusions, 1000Genome, Bodymap2, HPA, Non_Tumor_Cells, Babiceanu_Dataset, Banned_Dataset, GTEx_Dataset, Fimereli_Dataset, Cortex_Dataset, ChromothripsisDB databases.
  • Allows to map fusion genes to functional domain (Pfam databases)
  • Allows to map fusion genes to kegg/Biocyc pathway databases
  • Allows to check for non-protein coding fusion genes if any

FusionView module

  • Allows to visualize fusion events via three different modes of visualization

    • Circos view: provide a holistic picture of different chromosomes (inter and intra) involved in gene fusions via circos plot.
    • Domain view: allows to view different ways by which head/tail genes fused together and maintain domain integrity.
    • Network view: allows to explore fusion partnerships via gene fusion network

Oncofuse module

Oncofuse is a tool designed to predict the oncogenic potential of fusion genes. This module aids in running oncofuse for you.

siRNA designing module

This interface design siRNA sequences using a combination of 4 prediction tools namely BiLTR, siDirect, eRNAi and RNAxs.

Hope this will be useful. The paper is published here.

Please report any bug or suggest any ideas to improve the utility.

Thanks

Priyabrata

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