Job description: Positions for Postdoc Fellows are available at the Mount Sinai School of Medicine (Top-20 medical school in the US) in New York City. Our lab is in the Department of Genetics and Genomic Sciences and the Institute for Genomics and Multi-scale Biology.
Our lab (computation + experiment) pioneered the fast growing field of bacterial epigenomics (Nature Biotechnology, 2012). The widely used term “DNA methylation”, in most cases, refers to a specific form of cytosine methylation, 5mC, which has been widely studied. There are, in fact, other forms of DNA methylation across all kingdoms of life, yet challenging to detect using existing technology. We pioneered the use of third-generation sequencing (e.g. Single Molecule Real Time sequencing) to map the first bacterial N6-adenine (6mA) methylome at single nucleotide resolution (Nature Biotechnology 2012; Genome Research 2013; PLoS Computational Biology, 2013) and advanced the methodology to single molecule level analysis (Nature Communication 2015) and microbiome (Nature Biotechnology, 2018). Increasing evidence suggests that 6mA plays important roles in the regulation of molecular and cellular phenotypes in different bacterial pathogens. We have unique expertise in the use of third generation sequencing (single molecule real-time, ~20kbp read length, and the emerging nanopore technique) with advantages of detecting different types of DNA modifications, single molecule-level epigenetic phasing, complex structural variations.
Successful candidates will have unique opportunities to i) build on our unique expertise in 6mA epigenomics and third-generation long read sequencing, large scale collection of clinically relevant samples and a strong network of collaborators, ii) take the lead role in projects developing cutting edge technologies and innovative applications with high biological, biomedical and clinical impact. Compensations for successful candidates are highly competitive. Subsidized housing (in New York City) is also available.
Recent publications: Nature Biotechnology, 2018 * Genome Research, 2018 * Nature, 2016 * Cell Reports, 2016 * Nature Communications, 2015 * PLoS Genetics, 2015 * Biological Psychiatry, 2015 * Nature Communications, 2014 * Molecular Psychiatry, 2014 * PLoS Genetics, 2013 * PLoS Computational Biology, 2013 * Nature Biotechnology, 2012 * Genome Research, 2012
Lab page with details: http://research.mssm.edu/fanglab
Requirements: 1) Solid training in bioinformatics and statistics with next-gen data (DNAseq, RNAseq) experimental skills is a plus but not required. 2) Experience in comparative bacterial genomics, 3) Ability to learn and master new technologies and skills, 4) Abilities to lead an independent research direction while adapting to a collaborative environment, 5) An innovative yet critical thinker.
How to apply: Please send the following to firstname.lastname@example.org: 1) A brief cover letter, 2) CV with a list of publications, 3) PDF files for the papers in which you are first or co-first author.
Thank you for the interests!
Gang Fang, Associate Professor, Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, US