Is it possible to multiplex mora than 384 samples on Novaseq 6000 for a very low pass (0.5-10x) WGS?
Yes, if you have enough barcodes there’s no technical limitation. Also see this somewhat related question:
Splitting RNA-Seq data set on two (three) flow cells
Take-Home message: You can pool as many samples as long as you have enough unique primer/index combinations.
PerkinElmer has a set of 1536 NEXTFLEX UDI Adapters for ultra high-throughput multiplexing on Illumina flow cells.
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