I have a MAF-file with mutations from cbioportal. I want to detect cancer driver genes using R package dNdScv. Could you help me with using MAF file as dNdScv input? Should I convert MAF to another format?
Yes, to run dNdScv you need to provide the mutations in a simple 5-column dataframe, with the following columns: sampleID, chromosome, position, reference base, mutant base. You can follow the example in the tutorial below: