Hi all,
I have the list of genes (~6000) along with heritability values, heritability standard error and heritability p-value. I have calculated the z-score, p-values for z-score and FDR for each gene using R. After applying the threshold of z-score > 7 and FDR < 0.05, I have 841 genes. My ultimate goal is to see the association of the shortlisted genes w.r.t gene expression to a certain phenotype of interest. One approach might be doing the association test (logistic regression) followed by the permutations and calculating the empirical p-value for each gene? Will this be the right direction? What else direction can I follow?
As I am pretty new to this field, so my question may sound a bit naive, but I don't know how to proceed. Any guidance would be much appreciated!!!
Cheers,
Can you clarify the exact dataset(s) that you have? - genotype and expression data?