Question: Functional annotation chart from DAVID: Analogs or direct affiliations?
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16 months ago by
LRStar190
United States
LRStar190 wrote:

I am trying to determine if genes I am examining are honey bee affiliations or are human analogs. Basically, I:

1) Went to the DAVID bioinformatics software (https://david.ncifcrf.gov/).
2) Used "functional annotation" option.
3) Input a list of BeeBase IDs (all beginning with "GB", such as "GB41545") as a "gene list" with an identifier of “BeeBase_ID”.
4) Selected "functional annotation chart".

One result was KEGG_PATHWAY for Fanconi anemia pathway with 9 genes. So, I clicked on this pathway and, for each of the 9 genes within it, was given the BeeBase_ID, Gene Name, Related gene, and Species. For each of the genes, it does list the Species as Apis Mellifera (honey bee). One example gene is “Fanconi anemia group M protein(LOC409579)”. In NCBI, this gene information can be found at: https://www.ncbi.nlm.nih.gov/gene/409579. There, it also lists the organism as “Apis mellifera”.

Is this gene an insect affliction? Or, is it a human analog but I am simply looking at its related gene for honey bees?

functional david annotation • 432 views
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