PacBio base modifications merging p6c2 and p4c2

Question

[stolarek.ir]

When searching for modified bases in PacBio sequencing, can I merge datasets coming from 2 different polymerases: P6C2 and P4C2 to increase the coverage? Or will the pipeline be misled by such an attempt?

Answer 1

[richard.james.hall]

The models are most likely not that different, so it's worth a try.