Hi, I have some questions related to tlod in vcf file.
Please explain what I wonder.
I don't know exactly tlod in vcf file. I made vcf files by MuTect2 of GATK. If I read that file, it shows data (i.g. TLOD=1007.42). What is tlod?? Is it tumor log odds ratio or tumor likelihood ratio? And how do the tool calculate tlod? If the data is log, TLOD=1007.42 means too big number.
I want to get the reason why the default TLOD filtration cutoff is 6.3.