protein domain "official" DB

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4.8 years ago

cocchi.e89 ▴ 270

I'm working on some variants (exome, human) and I found the different outputs printed for each domain by VEP, e.g. : ex. VAR 1-949422-G-A : Gene3D:3.10.20.90&Pfam_domain:PF00240&PROSITE_profiles:PS50053&hmmpanther:PTHR10666&hmmpanther:PTHR10666:SF81&SMART_domains:SM00213&Superfamily_domains:SSF54236&Low_complexity_(Seg):seg I'd like to know from you expert guys, is there, among all these domains, a more "official" or "widely utilized" one?

Thank you very much for any help!

vep domains protein human variation • 2.2k views

ADD COMMENT • link 4.8 years ago by cocchi.e89 ▴ 270

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There is nothing "more" or "less" official. All the sources listed are valid domain databases.

ADD REPLY • link 4.8 years ago by GenoMax 141k

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I know, but I'd like to know if there's a more maintained, widely used etc. Maybe there's not

ADD REPLY • link 4.8 years ago by cocchi.e89 ▴ 270

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Pfam, PANTHER, PROSITE all do regular releases/updates so are certainly being actively curated.