Question: protein domain "official" DB
0
gravatar for cocchi.e89
5 months ago by
cocchi.e8930
cocchi.e8930 wrote:

I'm working on some variants (exome, human) and I found the different outputs printed for each domain by VEP, e.g. : ex. VAR 1-949422-G-A : Gene3D:3.10.20.90&Pfam_domain:PF00240&PROSITE_profiles:PS50053&hmmpanther:PTHR10666&hmmpanther:PTHR10666:SF81&SMART_domains:SM00213&Superfamily_domains:SSF54236&Low_complexity_(Seg):seg I'd like to know from you expert guys, is there, among all these domains, a more "official" or "widely utilized" one?

Thank you very much for any help!

ADD COMMENTlink written 5 months ago by cocchi.e8930

There is nothing "more" or "less" official. All the sources listed are valid domain databases.

ADD REPLYlink written 5 months ago by genomax75k

I know, but I'd like to know if there's a more maintained, widely used etc. Maybe there's not

ADD REPLYlink written 5 months ago by cocchi.e8930
1

Pfam, PANTHER, PROSITE all do regular releases/updates so are certainly being actively curated.

ADD REPLYlink written 5 months ago by genomax75k

thank you very much @genomax

ADD REPLYlink written 5 months ago by cocchi.e8930
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