DESeq2 uses GLM with negative binomial distibution to model the regressor for variance shrinkage. It is obvious that the expression variance is different for gene with different expression level and a ordinary linear model is not suited. I am wonder if it is possible to model this regressor using LOESS instead of GLM?
Question: Dispersion shrinkage in DESeq2: LOESS instead of negative binomial based GLM?
11 months ago by
CY • 510
CY • 510 wrote:
ADD COMMENT • link •
Please log in to add an answer.
Powered by Biostar version 2.3.0
Traffic: 960 users visited in the last hour