Question: Dispersion shrinkage in DESeq2: LOESS instead of negative binomial based GLM?
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gravatar for CY
14 days ago by
CY370
United States
CY370 wrote:

DESeq2 uses GLM with negative binomial distibution to model the regressor for variance shrinkage. It is obvious that the expression variance is different for gene with different expression level and a ordinary linear model is not suited. I am wonder if it is possible to model this regressor using LOESS instead of GLM?

rna-seq deseq • 78 views
ADD COMMENTlink written 14 days ago by CY370

You can ask the maintainer for an experts opinion at BioC (https://support.bioconductor.org/) but I would avoid the term obvious unless you are 100% sure what you are talking about and have experts knowledge on why things are modeled/used as they are.

ADD REPLYlink written 14 days ago by ATpoint23k
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