Decontaminate RNASeq data from other cell types?

Question

[pennakiza]

Hello all,

Very ambitious question coming!

So I have RNA-Seq data from CD4+ cells, which are selected using a kit. However I used CIBERSORT on them and I see that there is a significant contamination with other immune cell types, mainly B and NK cells. I was wondering if there is any way to extract only the cells of my interest?

Thanks and apologies in advance! :)