Question: How to distinguish subclone from sciClone or PyClone result
gravatar for bioxujintian
4 months ago by
bioxujintian0 wrote:

Hello everyone,

I used sciClone and PyClone to cluster mutations, but don't konw how to distinguish founding clone and subclone. I would really appreciate if someone could answer this question.

sciclone pyclone • 206 views
ADD COMMENTlink modified 5 weeks ago • written 4 months ago by bioxujintian0

Thanks, Miller. Do you mean the highest VAF cluster in a sample is the founding clone in this sample?

ADD REPLYlink written 5 weeks ago by bioxujintian0

Usually that is the case

ADD REPLYlink written 4 weeks ago by Chris Miller21k
gravatar for Chris Miller
5 weeks ago by
Chris Miller21k
Washington University in St. Louis, MO
Chris Miller21k wrote:

The founding clone is made up of the set of mutations that is in every cell of the tumor. It generally corresponds to the highest-VAF clone (which should be highest in all samples)

ADD COMMENTlink written 5 weeks ago by Chris Miller21k
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