How to distinguish subclone from sciClone or PyClone result
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16 months ago

Hello everyone,

I used sciClone and PyClone to cluster mutations, but don't konw how to distinguish founding clone and subclone. I would really appreciate if someone could answer this question.

sciClone PyClone • 675 views
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Thanks, Miller. Do you mean the highest VAF cluster in a sample is the founding clone in this sample?

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Usually that is the case

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13 months ago

The founding clone is made up of the set of mutations that is in every cell of the tumor. It generally corresponds to the highest-VAF clone (which should be highest in all samples)

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