I came across rMATS while doing research on differential alternative splicing (AS). It uses logit-normal distibution to model variation among biological replicates. I am having difficulty understanding the logics here.

Can anyone share some insights on how logit-normal distribution can model such variation? It does not have to be AS specific as long as the allow me to understanding the rational here.

Thank you for replying. I can understand the binomial distribution part. What confused me is the logic of using logit-normal distribution to model between-replicates variation