**110**wrote:

Dear All,

For survival analysis, firstly I ran univariate Cox model between my 71 cases and 180 genes.based on that, 70 genes had p-value less than 0.05. Now I would like to fit a multivariate Cox proportional hazards model among 70 significant genes based on below function for Overal Survival with 70 genes expression values:

```
multiple_cox_green_genes <- coxph(Surv(coxSARC_green_data$OS.days, coxSARC_green_data$OS.status) ~ ENSG00000076662 + ENSG00000204475 + ENSG00000111796 + ENSG00000115607+ENSG00000093072 +ENSG00000172543 +ENSG00000255833 + ENSG00000121807 + ENSG00000227507 + ENSG00000122224 + ENSG00000172215 + ENSG00000073861+ENSG00000137078 + ENSG00000182866 + ENSG00000100351 + ENSG00000104814 + ENSG00000196684 + ENSG00000143185 +ENSG00000122188 + ENSG00000128284 + ENSG00000110448 + ENSG00000176083 + ENSG00000113088 + ENSG00000117091 +ENSG00000186810 + ENSG00000205045 + ENSG00000271503 + ENSG00000116824 + ENSG00000266094 + ENSG00000125910 +ENSG00000153563 + ENSG00000198821 + ENSG00000143184 + ENSG00000005844 + ENSG00000147168 + ENSG00000153283 +ENSG00000009790 + ENSG00000078589 + ENSG00000121380 + ENSG00000141293 + ENSG00000169442 + ENSG00000167984 +ENSG00000026751 + ENSG00000117090 + ENSG00000174946 + ENSG00000213886 + ENSG00000162739 + ENSG00000183918 +ENSG00000124203 + ENSG00000110848 + ENSG00000163519 + ENSG00000161405 + ENSG00000115085 + ENSG00000101082 +ENSG00000113263 + ENSG00000125735 + ENSG00000106560 + ENSG00000163508 + ENSG00000089012 + ENSG00000100385 +ENSG00000125347 + ENSG00000117560 + ENSG00000163564 + ENSG00000172673 + ENSG00000163600 + ENSG00000125637 +ENSG00000172116 + ENSG00000145649 + ENSG00000008516 + ENSG00000183813 + ENSG00000160185 + ENSG00000109684
,data = coxSARC_green_data)
```

but I get below Error and warning:

```
Error in fitter(X, Y, strats, offset, init, control, weights = weights, :
NA/NaN/Inf in foreign function call (arg 6)
In addition: Warning messages:
1: In fitter(X, Y, strats, offset, init, control, weights = weights, :
Ran out of iterations and did not converge
2: In fitter(X, Y, strats, offset, init, control, weights = weights, :
one or more coefficients may be infinite
```

I appreciate it if anybody shares his/her comment with me for solving this Error.

Best Regards

**56k**• written 7 days ago by modarzi •

**110**