Repeated measures in GWAS and polygenic risk scores analyses
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18 months ago
kl ▴ 10

Hi,

I have genetic data and outcome data for about 700 people. 44 of them have a repeated measure about 2 years later. Is it appropriate to keep one observation for each individual (with repeated measures) (and if so, first or second- how to choose?) and remove the other observation? Or is it better to maybe perform a mixed-effects model GWAS?

Thanks in advance

SNP • 364 views
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18 months ago
kl ▴ 10

the reason for repeated measure is they were enrolled in a different study examining the same outcome measure

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7 months ago
yanlea • 0

There is a R package dealling with repreated measures for GWAS: https://rdrr.io/rforge/RepeatABEL/man/RepeatABEL-package.html

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