Question: Can I use the SCENIC package to analyze the transcription factors in the bulk RNAseq data?
0
gravatar for xiaoguang
7 months ago by
xiaoguang50
xiaoguang50 wrote:

The SCENIC package is software for the analysis of transcription factor activity and localized genes in single-cell transcriptome sequencing data, and the R package also scores the transcription factor activity of each cell.

can I use the pack for bulk seq?

rna-seq scenic • 285 views
ADD COMMENTlink modified 7 months ago by geek_y11k • written 7 months ago by xiaoguang50
2
gravatar for geek_y
7 months ago by
geek_y11k
Barcelona
geek_y11k wrote:

May be It’s not a good idea. One of the first steps in SCENIC is to build the co-expression modules. Do you have enough samples to build the co-expression modules with enough biological heterogeneity among them ? Also the AUCell doesn’t seem to work for bulk rna-seq data.

ADD COMMENTlink written 7 months ago by geek_y11k
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