Question: panel of normal files
0
gravatar for cocchi.e89
6 months ago by
cocchi.e89110
cocchi.e89110 wrote:

Simple question, I've searched the web for it but found no clear answer. How/where do you get Panel Of Normal files for different kits to use in GATK Mutect2 analysis?

Thank you very much in advance for any help!

ADD COMMENTlink modified 9 weeks ago by L_LANKA0 • written 6 months ago by cocchi.e89110
0
gravatar for L_LANKA
9 weeks ago by
L_LANKA0
L_LANKA0 wrote:

A Panel of Normal or PON is a type of resource used in somatic variant analysis. Depending on the type of variant you're looking for, the PON will be generated differently. What all PONs have in common is that (1) they are made from normal samples (in this context, "normal" means derived from healthy tissue that is believed to not have any somatic alterations) and (2) their main purpose is to capture recurrent technical artifacts in order to improve the results of the variant calling analysis.

https://gatk.broadinstitute.org/hc/en-us/articles/360035890631-Panel-of-Normals-PON-

So, I think you can make it handmade

ADD COMMENTlink written 9 weeks ago by L_LANKA0

https://gatk.broadinstitute.org/hc/en-us/articles/360035531092#2 It can be useful

ADD REPLYlink written 8 weeks ago by L_LANKA0
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