What Tools Are There For Making Regular Expression Motifs From Aligned Sequences?
1
3
Entering edit mode
12.0 years ago

I recently knocked together a little tool, SLiMMaker, for generating regular expressions from protein sequences (http://bioware.soton.ac.uk/slimmaker.html). It wouldn't be too hard to knock together some proper documentation for it but, before doing so, I was wondering whether anyone (a) thought it might be useful, and/or (b) knows of an existing tool elsewhere that already does the same job?

(Edit to clarify: this is not a motif-hunting application, like MEME, SLiMFinder, DILIMOT etc., it is a simple application that tries to build the best regular expression according to certain user-constraints (max amount of degeneracy, min aa frequency, min coverage) from already aligned short sequences. It was actually designed for taking a set of instances from the ELM database and redefining the motif based on those sequences alone - ELM incorporates a lot of experimental evidence that is not always represented by the known biological occurrences.)

motif protein • 4.2k views
ADD COMMENT
0
Entering edit mode

amusingly just a few days ago I posted about this tool in tools section - I will reclassify your post as a tool and delete mine

ADD REPLY
0
Entering edit mode

Thanks. Your tools post is more informative, though, and I really just want feedback about similar things around, so I'd prefer this as a question and your tools post to remain. (I've not posted much here, though, so that might constitute inappropriate doubling up, rather than adding clarity.) I've changed it back to a question for now but can add more information and change it back if you think it is better to have a single tools/question post!

ADD REPLY
0
Entering edit mode

sure no problem, I would change the title to be a question then, something like: Are there other tools similar to SLiMMaker?

ADD REPLY
0
Entering edit mode
12.0 years ago

The MEME suite can do all sorts of motif matching.

ADD COMMENT
0
Entering edit mode

It can but I am not aware of any tool in MEME Suite for converting a set of short sequences into a single regular expression according to certain constraints. (This is not really a motif-hunting problem.)

ADD REPLY

Login before adding your answer.

Traffic: 2842 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6