Hey everybody, I am currently informing myself about Whole exome sequencing (WES) and there are a couple of things that still confuse me:
1) I read that WES "does not permit deep sequencing". Can somebody elaborate why this is the case?
2) I checked this website to get an idea about coverage for WES and I did not understand, why it is necessary to have a much higher coverage for detecting SNV when using WES compared to whole genome sequencing (e.g. 100x vs 15x).
If anyone could answer these questions for me, I'd be very thankful!!
Thanks!