Conservative (unadjusted) p value histograms
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3.5 years ago
Mozart ▴ 330

Hello everyone,

I am working on a case study where distribution of p values, unfortunately, conservative rather than being anti-conservative. It's good to face difficulties as they forge your patience but I guess this is where it comes the hard bit.

Based on this post and this other post, it would appear that something is wrong with the test I am using (Wald test). I have found this link really useful because it seems to address the point but I am not sure how to prepare my data for fdrtool as I think I might have found an interesting approach to deal with my data. If someone has already had the same issue, could you please help me even posting the piece of code snippet needed for this step?

Thanks a lot.

RNA-Seq • 767 views

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