How could I normalize the data in my study?

Question

[Lettucehelen]

Hello!

I am doing a study where I compare codon structures in different genomes of the kingdoms Eukarya and Bacteria. Since these kingdoms vary a lot with their number of genes present in their genome, I have an uneven amount of data for each of the groups.

How can I normalize it? Should I make the groups so that they have the same number of genes? Should I modify my results somehow to take into account this difference?

I am completely lost and confused, so any advice is appretiated!

Thanks!