How to classify Tumor Mutation Burden into TMB high, medium and low groups ?
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20 months ago
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Tumor mutational burden (TMB) is a measure of the number of gene mutations inside the cancer cells. TMB of a tumor sample is calculated by the number of non-synonymous somatic mutations per mega-base in coding regions. The value obtained for TMB always ranges from 0 to 1 which never reaches 1. What is the minimal cut-off that can be assigned to classify TMB as High, Medium and Low?

exome tumor mutation burden TMB • 721 views
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20 months ago
Karma ▴ 310

There is specified cut-off for stratifying the tumor mutation burden.

You can go through these papers p1, p2, p3

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