How to classify Tumor Mutation Burden into TMB high, medium and low groups ?

Question

[svp]

Tumor mutational burden (TMB) is a measure of the number of gene mutations inside the cancer cells. TMB of a tumor sample is calculated by the number of non-synonymous somatic mutations per mega-base in coding regions. The value obtained for TMB always ranges from 0 to 1 which never reaches 1. What is the minimal cut-off that can be assigned to classify TMB as High, Medium and Low?

Answer 1

[Karma]

There is specified cut-off for stratifying the tumor mutation burden.

You can go through these papers p1, p2, p3