Is there any way to correlate VAF information with bulk-transcriptome expression after adjustment of purity and ploidy of the cancer samples? e.g., in one of the samples, I found that the VAF is 0.17, and the copy number of the samples is ~5 (after adjustment of purity and ploidy by the purple tool). Purple can adjust the variant copy number. But it seems very challenging how to correlate it with the bulk-RNA expression. Any suggestions for the best tool which can take care of tumor purity adjustment for mRNA expression from RNAseq?