Best tool/platform for identification of cancer driver genes

Question

[s.awasthy]

Hello all, i need to identify the cancer driver genes from human cancer data ( exome-seq). There are too many tools available for the analysis but maximum of them are not updated. Can anyone suggest me the best approach/tool for the same?

Answer 1

[Kevin Blighe]

There has recently (year 2020) been some further landmark studies in this area, and I would suggest to you that you re-use that information that has already been produced. If you want, you could, for example, take those genes that are already identified as drivers and try to find out some unique aspect about them that has not yet been discovered.

The studies in question are:

• A compendium of mutational cancer driver genes
• Identification of cancer driver genes based on nucleotide context

There is also useful information for you at Cancer Mutation Census

Finally, a rigorous search via a search engine of choice will help. I mean, literally, spend a full day searching and compiling information that you think may be useful.

Kevin

[s.awasthy]

Thankyou Sir..will surely follow your advice