Question: How to understand single nucleotide polymorphism (SNP)?
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gravatar for 2001linana
12 days ago by
2001linana20
2001linana20 wrote:

I was reading an article with title "characterizing sars cov 2 mutations in the united states" lately and got confused about SNP (single nucleotide polymorphism). On page 3 of this article, it mentioned that 4968 mutations are identified in 7823 strains. Then, it talks about "in this work, we extract 7823 single nucleotide polymorphism (SNP) profiles from genome isolates collected in the united states." So, why is it 7823 SNPs ? I thought that, more than likely, it should be 4968. Any comments are greatly appreciated.

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ADD COMMENTlink modified 12 days ago by jared.andrews078.0k • written 12 days ago by 2001linana20
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gravatar for jared.andrews07
12 days ago by
jared.andrews078.0k
Memphis, TN
jared.andrews078.0k wrote:

7823 single nucleotide polymorphism (SNP) profiles

So, they found 7823 SNP profiles, as they had 7823 strains. From these profiles, 4968 mutations were found.

ADD COMMENTlink written 12 days ago by jared.andrews078.0k

So, these are 7823 SNP profiles, not 7823 SNP's. Is this understanding correct ? So what are the difference between SNP profiles and SNP's then? And what is the meaning of "7823 SNP profiles are decoded from the genome isolates submitted by the US"? Being decoded means being identified?

ADD REPLYlink modified 12 days ago • written 12 days ago by 2001linana20

Is this understanding correct ?

Yes.

So what are the difference between SNP profiles and SNP's then?

"SNP profile" would correspond to the list of SNPs throughout the genome of a sample rather than a specific SNP.

And what is the meaning of "7823 SNP profiles are decoded from the genome isolates submitted by the US"? Being decoded means being identified?

In this case, yes. I feel decoded is a bit of a confusing word choice there.

ADD REPLYlink written 11 days ago by jared.andrews078.0k
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