Question: is this a typo in this article?
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gravatar for 2001linana
2 days ago by
2001linana10
2001linana10 wrote:

Hi. I was reading an article with title "topology entropy of DNA sequences". So, in the abstract, it said, "...We compute its expected value and apply this definition to the intron and exon regions of the human genome to observe that as expected, the entropy of introns are significantly higher than that of exons..." Then, in the last paragraph of the introduction part, "We will then apply this definition to the human genome to observe that the entropy of intron regions is in face lower than that of exon regions as one would expect." What's your opinion then?

sequencing sequence • 45 views
ADD COMMENTlink written 2 days ago by 2001linana10

"We will then apply this definition to the human genome to observe that the entropy of intron regions is in face lower than that of exon regions as one would expect."

There's a typo in your question: "face" needs to be changed to "fact"

I searched the paper in google scholar, and then searched "Koslicki" within the cited articles:

The article "DNA entropy reveals a significant difference in complexity between housekeeping and tissue specific gene promoters" says

(Koslicki, 2011, Jin et al., 2014) conclude that non-coding DNA has higher entropy than coding DNA

The article "A Generalized Topological Entropy for Analyzing the Complexity of DNA Sequences" says "

Recently, Koslicki [6] introduced a topological entropy for finite sequences and showed the complexity of introns is higher than that of exons for each chromosome.

Also this quote from the original paper, may help:

Interestingly, even though we observe that intron entropy is larger than exon entropy, the entropies of both regions are much lower than expected (here expectation is as calculated in Table 1).

ADD REPLYlink modified 2 days ago • written 2 days ago by Fatima820
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