False positives in homology
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16 months ago

I am wondering in case if there is a false positive in my homologs. How can we overcome the problem of false positives in homology?

homology sequence • 250 views
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This question needs far more detail in order to be answerable.

For starters: how is this list of homologues produced? In what sense are you considering something a false positive?

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Homologs are defined as pairs of sequences related to each other by common evolutionary decent from a common ancestor. Because the definition requires knowledge about the deep past that is impossible to ever have, it is philosophically impossible to know whether two sequences are genuinely homologs.

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