**430**wrote:

Hi,

I would like to compute correlation coefficient between two numerical vectors that represent MALDI-TOF data. The two vectors do not always have the same length, which makes cor() function to fail.

The difference is usually of 1 or 2 values (out of 100 or 200). I would like to insert a NA into the shorter vector, but my problem is to find where I have to insert the NA value. The masses vectors are aligned, but sometimes, one mass in vector 1 match 2 masses in vector 2. By hand, I am able to "find" where the shift occurs, but I don't know how to code this search.

Completed :

Here is an example :

mass1 is the first vector of masses. mass2 is the second vector.

I want to identify the intersection of the two vectors. However, we are dealing with biological data, so the masses are not exactly the same. We have to allow a delta to say that two close masses are equivalent. match1 is a boolean vector used to know which masses in vector 1 are found in vector 2. To compute this, i use a "window" so close masses are said to be equivalent. The window is coded in ppm (part per million), because the error in measurement is growing with the mass. So for a peak at mass 2000, I will allow a window of +/- 2, but for 20000, I will allow a window of +/-20.

The problem is that in a few circonstances, a mass in vector 1 is found to have a match in vector 2, but as the corresponding mass in vector 2 is lower, the window is smaller, and in the match2 vector, the value is FALSE. That's why at the end I have not the same length for match1 and match2 (but i should have). I have try to solve this problem, but to solve it exactly, it takes to much time to compute. That's why I wanted to just remove or add one value to have the same length for both vectors.

```
mass1 : ... 3711 3740 3818 3883 ...
match1 : ... 0 1 1 1 ...
mass2 : ... 3687 3747 3769 3817 3883 ...
match2 : ... 0 0 0 1 1 ...
```

Here you can see that 3818 match 3817, 3883 match 3883, but in vector 1 3740 match 3747, but the opposite is not true. At the end, the vector match1 is longer than vector 2 by one unit. The error comes from here. I would like to align to vectors like the one below to "add" or "remove" one value and have the same length :

```
matched masses in vector 1 : ... 2114 3245 3740 3818 3883 4254 4785 ...
matched masses in vector 2 : ... 2113 3247 3817 3883 4256 4785 ...
```

I'm sorry, it's hard to explain !

Would you know how to do this ? or if there is a way to compute corelation coeficient with two vectors of different length ?

Thanks a lot

Julien

**50**• written 8.1 years ago by Julien Textoris •

**430**

I kind of understand it, but it would be much easier to help you with a numerical example. Also, are you coding in R/perl/??

2.3kYes sorry for that, I edited the post above.

Julien

430You should get correlation of the data that shares the same class in the two vectors instead of adding 'NA' for missing class values in the shorter vector.

15kStill not really clear. Could you provide a small version of your problem (even with two fake vectors), so that we can see what exactly you are dealing with? I agree with Dk that adding NAs does not seem like the appropriate solution, but please provide an example, so that we can help you.

3.7k