Question: Inferring Ancestral Protein Sequences Using Mega
gravatar for Ncemami
8.4 years ago by
Ncemami10 wrote:

Is it possible to infer full ancestral protein sequences using MEGA? The reason I ask is that it seems like the only input to their ancestral reconstruction program is a newick tree, and not an MSA. Without knowing the actual sequences, I don't understand how it is possible to do any sort of reconstruction. If anybody has experience with this I would appreciate your feedback.

protein • 3.5k views
ADD COMMENTlink written 8.4 years ago by Ncemami10
gravatar for Josh Herr
8.4 years ago by
Josh Herr5.7k
University of Nebraska
Josh Herr5.7k wrote:

Yes, you're right, as with only a NEWICK tree, you can't predict ancestral states. Honestly, I hate using MEGA and would avoid using the program at all costs. I don't understand why anyone uses it, but, that's my opinion.

You can infer ancestral states using MESQUITE.

ADD COMMENTlink modified 8.4 years ago • written 8.4 years ago by Josh Herr5.7k
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