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Question: How To Get Orthologous Gene Id For Another Specie Without Alignment?
1
gravatar for GAO Yang
8.3 years ago by
GAO Yang • 250
GAO Yang • 250 wrote:

Hi~ I know that I can retrieve the ID of possible orthologous genes between two species by BioMart. For example, if I set the "dataset" as specie A, and "filter" as Orthologous Specie B Genes. The gene IDs of all possible orthologous in specie A will return.

But what i want to do is slightly different here. I have a list of ensemble genes IDs of takifugu (pufferfish), about 900. Now I need the orthologous gene ID of another specie which are corresponding to these genes in list. Is there any way to do it without alignment such as blast ?

Thanks for your opinion and suggestion !
sequence • 3.9k views
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written 8.3 years ago by GAO Yang • 250
0
gravatar for JC
8.3 years ago by
JC ♦ 12k
Mexico
JC ♦ 12k wrote:

Use the Compara API http://uswest.ensembl.org/info/docs/api/compara/compara_tutorial.html
ADD COMMENT • link written 8.3 years ago by JC ♦ 12k

This way can do. Thanks, JC. But maybe due to the net speed, my script can't reach a fine results often. I'd better stick to the biomart way to do it. Anyway, thanks for your help :)

ADD REPLY • link written 8.3 years ago by GAO Yang • 250
0
gravatar for karolos.chapple
8.3 years ago by
karolos.chapple • 0
karolos.chapple • 0 wrote:

I have recently discovered metaPhOrs. They have a very good Python API available on request. As far as I know they can only deal with UniProt IDs but if you can map your ensembl IDs to UniProt you can batch query metaPhOrs.
ADD COMMENT • link written 8.3 years ago by karolos.chapple • 0
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