Question: Which Version Of Gatk Do People Use
gravatar for William
8.1 years ago by
William4.7k wrote:

Does everyone use the latest and greatest or do people stick with older version because of specific functionality (tools, multithreading, bugs, license, formats ) of these versions?

By the way, GATK is going back to a full open source license for academic users with version 2.4. Some people might have decided to keep using < 2. 0 version because of the closed source of the early 2.x versions.

I am currently using and older (1.6 )version and looking to which version I should upgrade.

gatk • 3.3k views
ADD COMMENTlink modified 8.1 years ago by Jorge Amigo12k • written 8.1 years ago by William4.7k
gravatar for Jorge Amigo
8.1 years ago by
Jorge Amigo12k
Santiago de Compostela, Spain
Jorge Amigo12k wrote:

I did open a discussion in the GATK forum regarding this issue, as you may check here. what I was asking was very simple, when they raised that version 2 that changed GATK as we knew it: should we stay with latest version 1.6, should we go for version 2 full, or should we go for version 2 lite? I should say that I first thought to do what you did, to stay with my 1.6 version I had already optimized and integrated in my pipeline, but Mark DePristo's answer was very clear: if you would like to continue with the 1.6 development you should go for version 2 lite, and if you would prefer to include the latest (and rather radical) changes and modules developed then you should go for version 2 full.

as you say, GATK's team has recently stated that they're about to merge both efforts, because it didn't make sense for them to maintain 2 different branches of the same concept. what they've stated is that version 2.4 would be only the 2.4 full, and that the lite version will no longer evolve. so if you want to stay with the previous algorithms then you shouldn't stay at 1.6, but at 2.3 lite. if the reason is algorithmic I could understand your point, but if the reason is the license type this will change with version 2.4, where they'll not only release it freely again, but also they'll open the source code again. as you may have already imagined, I'm currently using the latest full version, and I would honestly not see any reason why someone would prefer not to update. it's true that even if they've improved a lot the multithreading capabilities I had before (versions <2) slightly better performance, but the quality and reliability of the results that we are obtaining are not comparable.

ADD COMMENTlink written 8.1 years ago by Jorge Amigo12k

GATK-lite was removed from the Broads FTP site on Friday as far as I can tell, so the only option is to get on GitHub.

ADD REPLYlink written 8.1 years ago by User 5913k

That's actually not the case; GATK-Lite version 2.3 is still available for download from our website and will remain there until we release version 2.4 (which is tentatively scheduled for next week).

ADD REPLYlink written 8.1 years ago by vdauwera990

Well the link from your website was not working on Friday so what else were we meant to conclude? Certainly I couldn't (and still can't) download it from a browser from the link on your website. However I was able to access it today, using a 3rd party FTP client.

ADD REPLYlink modified 8.1 years ago • written 8.1 years ago by User 5913k
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