Question: 23Andme Genotype For X Chromosome: Some Have Two Bases, Others Have One
gravatar for jeff.hammerbacher
7.6 years ago by
United States
jeff.hammerbacher110 wrote:

I've downloaded my raw data from 23andMe. I'm a male. For most loci on the X chromosome, there is a single base in the "genotype" column. However, at the beginning and end of the chromosome, for a few hundred loci, there are two bases in the "genotype" column.

I've looked at my wife's 23andMe data, and her X chromosome has two bases for every loci on the X chromosome.

Where can I learn more about which loci in the X chromosome have one base versus two bases in a male? In particular, can I determine from the position number whether there will be one or two bases? Clearly I can come up with a decision rule based on manual inspection of the 23andMe data, but I'm curious if there's a rule that covers genomic loci that 23andMe does not yet measure.

ADD COMMENTlink modified 7.6 years ago by Pierre Lindenbaum130k • written 7.6 years ago by jeff.hammerbacher110
gravatar for Pierre Lindenbaum
7.6 years ago by
France/Nantes/Institut du Thorax - INSERM UMR1087
Pierre Lindenbaum130k wrote:

These loci might be localized in the PAR regions


At either end of the X and Y chromosomes are homologous regions known as the pseudoautosomal regions (PARs). These two regions pair regularly at male meiosis and undergo recombination. PAR1 is at the tip of the short 'p' arms (Xp22 and Yp11) and PAR2 is at the tip of the long 'q' arms (Xq28 and Yq12).

ADD COMMENTlink written 7.6 years ago by Pierre Lindenbaum130k

Thanks! FYI, I found the locations of the PAR regions for the 23andMe reference genome at

ADD REPLYlink modified 7.6 years ago • written 7.6 years ago by jeff.hammerbacher110
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