I have some doubts on Docking. I have modeled out a structure from homology modeling and perform some refinement. Now, there are two substrates to be introduced to the protein structure. The protein that I am studying is an enzyme and it catalyzes the reaction of two substrates. I have read about docking with one substrate / ligand, but not with two. How can I possibly do that? Any article references or advice please?
Thanking you in advance.
Best regards, Elmo