Power Calculation For The Replication Of The Snp Association With Quantitative Trait
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9.2 years ago
Ezhil La ▴ 10

Hi,

We have identified a SNP that is associated with the quantitative trait in the discovery study (n = 1500). Now, we wanted to replicate this SNP association. What is the sample size that is required for the replication study (to reach 80% power)? The beta value for this SNP is 0.02 and it has 48% allele frequency (minor).

Can we use the 2-stage power calculation for this purpose?

Thanks in advance.

Kind regards, Ezhil

gwas snp • 2.6k views
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