I have been analyzing the gene -
BRAF. I realized that this gene has a mutation which is present in both
chr7 140453129 chr7 140481476
Both these single base mutations are present in COSMIC and dbSNP. In COSMIC these mutations are labeled as
My understanding is that dbSNP has common mutations and COSMIC has mutations which are specific only for cancer. When I do variant analysis, I remove the common mutations, here dbSNP mutations and keep only COSMIC database mutations. But if I do this step now, I will be missing these mutations which are present in COSMIC.
Does anyone know why this occurs?