Hi, I’m Dynah, here I want to introduce you a novel platform for PEGylation which is commercially available at Creative Biomart. Please don’t treat this as an advertisement, I think you’d like to know another technique.
PEG-CtrlTM is a novel site-selective PEGylation platform, using a proprietary efficient and cost-effective PEGylation chemistry, which is suitable to a large variety of proteins.
We know the common limits for therapeutic application of peptides and proteins are their chemical instability, their short residence time in blood and their tendency to promote an immunological response. Most of these problems may be solved by linking one or more PEG (polyethylene glycol) molecules to these peptides and proteins (PEGylation). This is achieved due to the combination of increased molecular weight and coverage of epitopes or blockage of sequences prone to enzymatic degradation. In addition, PEGylation enhances protein solubility in aqueous solutions.
The PEG-CtrlTM unique approach enables homogeneous PEGylated populations where the specific PEGylation site can be selected and controlled, thus improving efficacy compared to existing PEGylation techniques, decreasing cost of goods and substance dosed to patient; while still providing an improved ADME profile due to the addition of the PEG moiety.
If you have further interest, please refer to http://www.creativebiomart.net/pegylationservices.htm or contact them which I believe you will found more than this.
Thanks for your patience.
