Question: What Makes A Phylogenetic Tree Interesting?
3
gravatar for Michael Dondrup
7.1 years ago by
Bergen, Norway
Michael Dondrup48k wrote:

... or how to automatically detect "novelty" in phylogenetic trees?

Today, I have a question about one of my weak spots, phylogenetics, sorry if it is a bit vague.

Imagine we have a set (>10k) of automatically generated (unrooted) trees for groups of homologous genes for a newly sequenced organism. Assume the tree generation is more or less sane (which is possibly not true for all trees ;) ).

  • Which could be criteria to screen for genes with "interesting" characteristics in their trees for further study? Looking for indicators e.g. of horizontal gene-transfer, co-evolution, convergent evolution, or differences in selective pressure, etc.
  • Which could be good criteria for filtering out crap trees (which I am sure exist, for example those looking like a comb, all branches have equal length, possibly because of errors in orthologue selection).
  • Which algorithm or software could be used to accomplish the above?

My ideas:

  • Define a consensus evolutionary tree (either from literatures or set of selected genes or all genes) and calculate tree difference (e.g. Robinson-Foulds metric). Possibly normalize by number of branches?
  • Use taxonomic information, e.g. to detect "out-of-clade" trees, where "my organism" is situated closest to members of a different clade than it has been classified in.

I searched for +"novelty detection" phylogenetic tree and similar terms but I didn't spot an article where this was applied automatically.

phylogenetics evolution tree • 2.2k views
ADD COMMENTlink modified 7.0 years ago by Biostar ♦♦ 20 • written 7.1 years ago by Michael Dondrup48k
2
gravatar for Biojl
7.1 years ago by
Biojl1.7k
Barcelona
Biojl1.7k wrote:

Maybe you want to take a look at the first part of this paper:

Genome-wide signatures of convergent evolution in echolocating mammals

ADD COMMENTlink written 7.1 years ago by Biojl1.7k
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