VEP Disk Space

Question

[Filago]

Hello,

I want to annotate VCF-files with VEP and want to use the CADD-plugin. This I want to do on a local computer (1 TB SSD/64GB Ram). My question ist, how the data for VEP annotation is stored? Is e.g. ALL the CADD-Data for the entire genome stored on my local computer? Or in easier words...does installing VEP + CADD need large disk space and is not feasible on local computers?

Best, Andreas

Answer 1

[Emily]

The GRCh38 release 103 VEP cache on my machine (domestic Mac, no cluster) is 17 GB. The unannotated CADD file from here is 81GB.