I want to annotate VCF-files with VEP and want to use the CADD-plugin. This I want to do on a local computer (1 TB SSD/64GB Ram). My question ist, how the data for VEP annotation is stored? Is e.g. ALL the CADD-Data for the entire genome stored on my local computer? Or in easier words...does installing VEP + CADD need large disk space and is not feasible on local computers?