Hello,

I have RNA time-course data and am looking to benchmark two different DESeq2 models I want to use. One design models time as a categorical variable, while the other design models time as a continuous variable. I am wondering if anyone knows of any R packages or methods to compute values such as AUROC to compare these two models performance in detecting DEGs.

Thank you

Do you have a set of validated DEGs (from another source of data) that can serve as the ground truth for your DESeq2 models? Is this in-silico RNA-seq data or real experimental data?