I would like to analyze the functional consequence of the mutation in the protein-coding region of the human genome like in TP53 or EGFR etc. I tried Annovar, VEP, SIFT, polyphen, etc but as far as know that most of the output from these tools is based on some predefined criteria rather than literature or experiments. Therefore output from these tools may not be biologically relevant or correct unless validated by experiments. I am searching for the database that host the information about biological consequence validated from experiment and also continually updated from the published literature.
Human genome Pathogenicity database would also work but I need database which is continuously updated or recently released/published.
Please help me. Thanks in advance.