I'm a bit new to the computational biology scene, and I would like information regarding how protein annotations are curated and how individuals can submit protein annotations. I ask because my team and I recently published a paper that shows the function of a protein with a pre-existing annotation is very different from what the annotation suggests. My question now is, do I request updates to the extensive public databases (e.g., NCBI/Pfam/etc.), or is this something that people who curate these databases do themselves?
Can someone provide a general guide as to how to ask these databases to update an entry, and whether that is possible?
Also see: How to get Genbank to update wrong annotations?